Efficient spatial allocation of municipal solid waste (MSW) collection infrastructure is essential for improving urban environmental management, service accessibility, and territorial equity in high-density metropolitan areas. In this study, the territorial and operational performance of MSW collection point optimization was assessed through the application of a Christaller-based hexagonal model in Los Olivos District, Lima, Peru. A quantitative, applied research approach was adopted under a comparative cross-sectional and non-experimental design, in which the existing collection configuration was systematically compared with an optimized spatial scenario. The baseline system consisted of 23 temporary accumulation/storage points (K3) distributed under operationally functional but territorially heterogeneous conditions, whereas the optimized configuration comprised 59 proposed K3 points spatially redistributed to enhance accessibility and service uniformity. The optimized network was generated using a regular hexagonal tessellation with a a circumradius of $R$ = 300 m per K3 point, corresponding to a pedestrian service radius/apothem of $\sim$260 m. Each hexagonal service unit covers approximately 0.2338 km$^2$, which was subdivided into 16 analytical zones. Spatial modelling and geostatistical processing were conducted using official cartographic datasets, population density layers, collection route information, Geographic Information Systems (GIS), Euclidean distance matrices, and geometric optimization procedures. Performance was evaluated using key indicators, including primary collection points/containers (K2)–K3 distance, K3–main road distance, estimated collection time, average MSW load per K3 point, population coverage, and territorial coverage. Statistical consistency was assessed using paired Student’s $t$-tests and Wilcoxon signed-rank tests with a significance threshold of 1%. Under the optimized scenario, the average K2–K3 distance was reduced from 413.78 m to 224.38 m, corresponding to a 45.76% reduction. The average MSW load per K3 point decreased by 61.03%, estimated sector-level collection time decreased from 11.50 min to 6.79 min, and territorial coverage increased from approximately 32% to 77%. Population coverage also increased from 33.17% to 78.88%. These findings suggest that the Christaller-based hexagonal model provides a scalable and reproducible spatial planning framework for optimizing MSW collection infrastructure in densely populated urban districts.