Surface ozone is a major secondary air pollutant carrying significant implications for the stability of the ecosystem, public health, and climate forcing. In Nigeria, rapid urbanization, emission growth, and climatic variability interact to shape ozone dynamics; however, there is little understanding of the specific contribution of meteorological factors. This study investigated the influence of key meteorological variables on surface ozone variability in Nigeria based on a combined Principal Component Analysis (PCA) and Linear Regression (LR) framework. Meteorological parameters include temperature, wind speed, relative humidity, rainfall, cloud cover, short-wave radiation, and atmospheric pressure. PCA results revealed that the first three principal components (PCs) explained approximately 76% of the total variance, suggesting that a limited number of climatic modes, primarily associated with temperature, wind speed, and humidity, dominated ozone variability. LR further quantified the individual contributions of these variables. Cloud cover (-1.015), temperature (-0.975), and wind speed (-0.665) exerted the strongest negative influence on surface ozone concentrations. In contrast, rainfall (0.306) demonstrated a positive association, potentially linked to enhanced post-precipitation soil NO$_x$ emissions. Other variables, including short-wave radiation, atmospheric pressure, and relative humidity, exhibited relatively minor effects. While the model reflected robust predictive performance (Mean Squared Error (MSE) = 0.044), the findings emphasized the significant role of meteorological processes in shaping ozone variability. In drastically urbanizing tropical regions, meteorological dynamics should be incorporated into the forecast of air quality and planning of environmental policies.