Pharmaceutical transport logistics, especially in humanitarian and hospital contexts, is becoming increasingly essential with a growing need to monitor associated costs. In Morocco, however, studies focusing on the cost implications of pharmaceutical delivery conditions are conspicuously absent. This creates a high-dimensional classification framework, where the selection of variables becomes challenging in the face of correlated distribution predictors. The integration of Artificial Intelligence (AI) in cost prediction has emerged as a vital necessity amidst escalating complexities and cost considerations. Cost prediction, being inherently correlated with almost all variables and inputs, offers an interpretable value in performance management, financial planning, and contract negotiation. This study undertakes a comparative analysis of a broad spectrum of prediction algorithms applied to the same, albeit reduced, database. A dozen such algorithms are put into practical use, with variable selection implemented through importance measures. The primary objective of this comparative evaluation is to determine the superior performing algorithm — one that delivers optimal adaptation to the context within a fixed environment. The prediction algorithm incorporates a myriad of inputs and constraints derived from data collection systems. AI's application facilitates the inclusion of diverse variables such as transportation routes, congestion, distances, freight weight, and environmental factors, thereby enhancing the accuracy and efficiency of cost estimation. The Orthogonal Matching Pursuit model emerged as the most successful, boasting an R² value nearing unity. Accurate cost prediction in transport can yield valuable insights into budgeting, estimation, customer service, managerial risk, environmental considerations, and strategic deployment for a company. Improved decision-making and resource allocation can thereby be achieved, leading to enhanced profitability and sustainability.