Eutrophication, defined as excessive nutrient enrichment in aquatic ecosystems, has been increasingly recognized as one of the most critical drivers of freshwater and coastal ecosystem degradation worldwide. A qualitative research framework based on systematic literature synthesis, statistical data interpretation, and comparative regional case analysis was employed to examine the systemic drivers and socio-ecological consequences of nutrient pollution. Case studies from India and the United States were comparatively analyzed in order to identify recurring patterns of nutrient loading and ecological outcomes. It is demonstrated that excessive nutrient inputs substantially increase the frequency and severity of harmful algal blooms, which subsequently contribute to hypoxic or anoxic conditions, biodiversity loss, and the structural destabilization of aquatic food webs. These ecological transformations are shown to generate cascading socio-economic impacts, particularly for fishing-dependent and agrarian communities whose livelihoods are directly linked to aquatic ecosystem services. The analysis further indicates that climate change amplifies nutrient cycling dynamics and accelerates eutrophication processes. To address these challenges, integrated mitigation strategies emphasizing watershed-scale nutrient management, improved wastewater treatment infrastructure, and strengthened environmental governance were critically evaluated. Community-based resource management and participatory water governance mechanisms were identified as essential components for enhancing ecological resilience and long-term sustainability. The findings highlight the necessity of systemic policy reforms that prioritize nutrient pollution control, sustainable agricultural practices, and coordinated water governance frameworks in order to mitigate the escalating environmental and socio-economic consequences of eutrophication.