The COVID-19 pandemic significantly challenged business resilience, particularly in the healthcare sector, where pharmaceutical and biotechnology companies experienced growth and service-oriented entities faced operational stress. In this study, the advanced Multi-Criteria Decision-Making (MCDM) techniques were employed to investigate the financial performance of healthcare firms listed on the Standard and Poor's 500 index from year 2018 to 2023. The research evaluated ten firms based on 16 criteria, encompassing both financial and non-financial dimensions. The financial criteria included Leverage Ratio, Tobin's Q Ratio, Revenue Growth, Operating Profit Growth, Equity Growth, Firm Size, Net Income, Total Liabilities, Revenue, Operating Profit, and Market Capitalization. In parallel, the non-financial indicators such as Human Resource Management, Supply Chain Management, Risk and Crisis Management, Business Ethics, and Environmental Policy were integrated to reflect managerial quality and sustainability practices. Out of the 16 criteria, two costs and nine benefits were quantitative whereas the remaining five benefits were qualitative. Expert assessments were modeled on the Spherical Cubic Fuzzy (SCF) sets and aggregated with the Aczel–Alsina operator. Alternatives were ranked using methods like the Ranking of Alternatives through Nested Cumulative Operator Method (RANCOM) and the Alternative Ranking Order Method with Adjustment Normalization (AROMAN), hence producing a multidimensional evaluation matrix enriched by both numerical and verbal judgments from ten experts. This research contributed to the literature in three key ways: (1) It provided a holistic assessment of financial performance in a highly dynamic and uncertain environment; (2) It broadened the performance evaluation framework to include non-financial and sustainability-driven criteria; and (3) It demonstrated the utility of novel MCDM tools like the SCF sets, the Aczel–Alsina aggregation, the RANCOM, and the AROMAN in complicated decision environments. The study offers a robust and innovative analytical model for academics and practitioners seeking to understand firm resilience and performance amid crises.